# Matt Kaeberlein — Researcher persona

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- Persona: Matt Kaeberlein
- Summary: Durable Researcher corpus for Matt Kaeberlein: peer-reviewed geroscience research (rapamycin, mTOR, the Dog Aging Project), reviews, talks, and interviews with entity-owned source snapshots and indexes.
- Page: https://researcher.now/e/matt-kaeberlein
- JSON: https://researcher.now/public/entities/by-slug/matt-kaeberlein?include=all
- Sources: 99
- About report version: v3

## About

Kaeberlein’s public pattern is disciplined interventionism: he argues that aging is biologically modifiable and worth targeting upstream of disease, but he treats every attractive longevity claim—rapamycin, diets, clocks, supplements, “reversal”—as provisional until it survives rigorous definitions, controls, dosing logic, functional endpoints, and translational tests. That stance matters because he occupies a rare position in longevity science: a builder of optimistic geroscience infrastructure, especially around rapamycin and the Dog Aging Project, who simultaneously polices the field’s credibility against premature consumer claims and sloppy measurement. [46cdaae5-8a2c-46ec-ab84-71688e753fa7, c07d0ae5-1871-4232-bb71-d473af342d82, 9991ff53-4225-47d9-b41c-1d408e4772e1, 7453a67b-e3fc-4142-8d8b-a150e25538ed]

## Recurring interests and themes

- **Aging as upstream medicine:** His core research frame is geroscience: target the biology of aging to delay multiple chronic diseases and functional declines, rather than waiting for cancer, cardiovascular disease, dementia, kidney disease, or frailty to appear one at a time. [46f2e5c9-8a5a-4f18-8238-4e9ac6e9ac36, 8b773a71-6629-4268-8ffb-e634d07f012d]
- **mTOR as a conserved control node:** He repeatedly returns to TOR/mTOR because nutrient-responsive TOR and Sch9 pathways regulate lifespan in yeast, mTOR inhibition extends lifespan across model organisms, and mTOR links diet, growth, autophagy, immune function, and age-related pathology. [08b666dd-92ba-45d9-a092-5f4c76936d3f, bb789502-5137-410a-954e-b795c7245ef2, 8b64aa70-d1bd-4ad9-b2f2-aec415dc86ba]
- **Rapamycin as the exemplar intervention:** Rapamycin is his model case for translating conserved aging biology responsibly: it is one of the most reproducible pharmacological lifespan-extending interventions in animals, but he frames it through dose, timing, route, sex effects, safety, biomarkers, and clinical endpoints rather than miracle-drug rhetoric. [810e2339-9721-4f4a-b1cb-055ff645d1e6, 7432e379-23da-4f3b-b84b-efe6214a76bf]
- **Companion dogs as a translational bridge:** The Dog Aging Project expresses his belief that pet dogs can connect laboratory geroscience to real-world aging because they share human environments, veterinary care, age-related diseases, genetic diversity, and shorter lifespans. [070a08eb-b239-4f33-a4d3-979957108a19, 2ee53943-d57a-4297-ae7c-18f14ac5da47]
- **Functional aging over molecular theater:** He consistently privileges functional decline—heart function, grip or strength, frailty, cognition, organ function, activity, quality of life—over changes in a molecular proxy that may not improve how an organism actually functions. [157680c4-4dba-4e64-b398-944aade54b2a, 143adea2-995d-450e-97ec-b8130e7a01ad]
- **Biomarkers with restraint:** He is interested in epigenetic clocks, metabolomics, extracellular vesicles, clinical labs, DEXA, CGMs, and wearable-style diagnostics, but treats them as candidates that must predict meaningful outcomes rather than as direct measurements of “biological age.” [6a795436-bb7e-442b-8e23-7d9e451f6eb3, cc6b772c-a46d-4edd-a850-5d5c1821698d]
- **Nutrition as pathway biology, not diet ideology:** His dietary work places caloric restriction, fasting, protein restriction, and anti-aging diets inside nutrient-sensing biology, while warning that genotype, environment, adherence, malnutrition risk, immune effects, and human feasibility make broad prescriptions premature. [c1e4811d-63f7-4ed7-b3da-e7fbcec837a1, 69f379c8-bb04-4f13-ae7a-b3d16c8025ef]
- **Longevity demystification:** In public settings he repeatedly distinguishes hope from hype—skeptical of NAD boosters, resveratrol, fisetin, consumer clocks, “reversing aging,” and supplement marketing while still defending the scientific plausibility of targeting aging. [7453a67b-e3fc-4142-8d8b-a150e25538ed, ba5330b5-10ca-429b-97de-1e4999c3f093]

## Beliefs and principles

- **You do the experiment:** His scientific ethic is anti-dogmatic: plausible mechanisms and expert intuitions are not enough, because interventions must be tested rather than assumed from favored theories. [7b6b7929-11d6-4a31-b8a3-30194371884d]
- **Partial understanding can still justify intervention:** He does not claim aging is fully understood, but argues that enough is known about molecular mechanisms to generate rational interventions whose predictions must then be tested. [157680c4-4dba-4e64-b398-944aade54b2a]
- **Language precision protects trust:** He sees imprecise claims—“healthspan extension,” “biological age,” “reversal,” “cure aging”—as credibility risks for the whole field, especially when scientists or clinicians overstate what measurements show. [7453a67b-e3fc-4142-8d8b-a150e25538ed, c07d0ae5-1871-4232-bb71-d473af342d82]
- **Endpoints must matter clinically:** A biomarker change is not persuasive if it does not map to future disease, mortality, function, resilience, or quality of life; for him, function is the scoreboard that molecular measures must eventually answer to. [143adea2-995d-450e-97ec-b8130e7a01ad, 6a795436-bb7e-442b-8e23-7d9e451f6eb3]
- **Risk–reward beats novelty:** He evaluates interventions by reproducibility, dose plausibility, purity, side effects, practical feasibility, human relevance, and opportunity cost—not by whether they sound mechanistically elegant or popular. [ba5330b5-10ca-429b-97de-1e4999c3f093, 0a004b78-0786-415c-87de-2364a3aa40ce]
- **Lifestyle is the current foundation:** Even while studying pharmacological geroprotectors, he emphasizes eating well, moving, sleeping, and connecting as the highest-confidence levers because they influence aging biology and are more grounded than most marketed longevity products. [3e794561-7e4f-4127-b1d5-ee0bd502d194, d3efc056-06ae-4877-af68-4ef48dc6586d]
- **Open science accelerates translation:** His Dog Aging Project values public participation, open data, biospecimen sharing, community science, and multi-institutional collaboration as infrastructure for discoveries that no single lab could produce alone. [070a08eb-b239-4f33-a4d3-979957108a19, 955ea80b-77d4-4b21-ad3f-577827e77d9f]
- **Controls define credibility:** His 900-day-rule critique reflects a broader principle: lifespan-extension claims are only as strong as their controls, because short-lived or unhealthy controls can make weak interventions look transformative. [9991ff53-4225-47d9-b41c-1d408e4772e1]

## Future narratives and predictions

- **Medicine should move from disease-first to aging-first:** He expects 21st-century medicine to increasingly target aging biology to improve health and longevity, contrasting this with the older model of treating diseases only after pathology is established. [46cdaae5-8a2c-46ec-ab84-71688e753fa7]
- **Rapamycin needs decisive human trials:** He sees rapamycin’s animal evidence and early translational signals as strong enough to justify large, well-designed human clinical trials, while acknowledging that current human evidence cannot yet establish dose, benefit, or safety for healthy aging. [2c1c34a4-7de3-483b-bf3e-5921c08beb10, 0bfec364-36e0-4966-80e3-b0a0448b7903]
- **Selective mTORC1 inhibition is a likely next frontier:** Reviews in his orbit point toward safer, more selective mTORC1 inhibitors as a future route for translating mTOR biology while reducing side effects associated with broader or prolonged mTOR inhibition. [4dd15d90-0ebb-420e-bd65-966fc3600120, 8b64aa70-d1bd-4ad9-b2f2-aec415dc86ba]
- **Dogs can shorten translational timelines:** The Dog Aging Project’s long-term observational cohorts and TRIAD trial create a future in which aging interventions can be tested in a heterogeneous large-mammal population far faster than lifespan trials in humans. [4e0e624c-5501-4531-9591-6aa542d213e4, 070a08eb-b239-4f33-a4d3-979957108a19]
- **Biomarkers will become useful, but probably multi-modal:** He expects predictive aging diagnostics to emerge from combined molecular, clinical, imaging, functional, and possibly facial or wearable data rather than from epigenetic clocks alone. [143adea2-995d-450e-97ec-b8130e7a01ad, 1b06ebf7-a0a1-4a6b-87a8-85437c95cdc9]
- **Discovery science remains necessary for larger gains:** He argues that current interventions are useful but not close to “curing aging,” and that major lifespan and healthspan advances require mapping unknown parts of aging biology rather than only refining today’s favored pathways. [7453a67b-e3fc-4142-8d8b-a150e25538ed]
- **Consumer longevity will remain noisy unless clinicians and evidence standards catch up:** His public comments imply that the market for tests, supplements, peptides, and off-label interventions will keep outrunning validation unless medical interpretation, trial evidence, and scientific communication improve. [302f111f-88eb-4e5c-8ff7-0726f697b61c, d3efc056-06ae-4877-af68-4ef48dc6586d]
- **Healthspan progress will likely be incremental, not immortalist:** He rejects claims that aging is optional or already reversed, while still arguing that delaying disease, improving function, and compressing sick span are realistic and socially valuable goals. [7453a67b-e3fc-4142-8d8b-a150e25538ed, c07d0ae5-1871-4232-bb71-d473af342d82]

## Recurring questions

- **What exactly is aging?** He repeatedly asks whether aging is best defined molecularly, functionally, physiologically, as disease risk, as loss of resilience, or as a network of dysregulated hallmarks—and he treats definitional clarity as necessary for meaningful claims. [46cdaae5-8a2c-46ec-ab84-71688e753fa7, c710ad0f-5347-443a-9a4a-0e27e1d62285]
- **When is disease still aging biology, and when has pathology become something else?** He often distinguishes prevention from treatment: an aging mechanism may help initiate a disease, but once pathology changes, the same intervention may no longer work. [157680c4-4dba-4e64-b398-944aade54b2a]
- **What dose, timing, and regimen make rapamycin geroprotective rather than harmful or ineffective?** His rapamycin questions recur around late-life versus early-life treatment, transient versus continuous dosing, tissue specificity, mTORC1 versus mTORC2, formulation, sex effects, and whether human regimens are biologically meaningful. [bb789502-5137-410a-954e-b795c7245ef2, 147151e2-c737-4a65-9785-918fca4ff95e]
- **Which endpoints can prove healthspan extension?** His healthspan critique asks what should count as a validated, quantitative, multidomain measure of “good health” if health is continuous, dynamic, and partly subjective. [c07d0ae5-1871-4232-bb71-d473af342d82, 021ed7e4-97e7-442d-a825-afdef8b90842]
- **Can companion dogs predict human aging interventions?** The Dog Aging Project asks whether genetic diversity, shared environment, owner and veterinary records, biospecimens, activity data, mortality surveys, and randomized trials in dogs can identify mechanisms and interventions relevant to humans. [2ee53943-d57a-4297-ae7c-18f14ac5da47, 4e0e624c-5501-4531-9591-6aa542d213e4]
- **Which biomarkers forecast future outcomes rather than current correlations?** His standard for clocks and biomarkers is whether they predict individual future health, disease, function, or survival—not merely whether they correlate with chronological age or mortality in populations. [cc6b772c-a46d-4edd-a850-5d5c1821698d, 6a795436-bb7e-442b-8e23-7d9e451f6eb3]
- **How much animal evidence should change human behavior?** He repeatedly interrogates whether caloric restriction, fasting, protein restriction, rapamycin, NAD boosters, metformin, and supplements translate from controlled model systems into heterogeneous human lives. [c1e4811d-63f7-4ed7-b3da-e7fbcec837a1, 418ba565-b6a1-42a9-a61b-cc53b9c18f50]
- **How should a rational person act amid uncertainty?** His public advice often comes down to risk–reward judgment: prioritize high-confidence lifestyle and clinical prevention, treat speculative interventions as uncertain, and avoid confusing personal experimentation with proven medicine. [0a004b78-0786-415c-87de-2364a3aa40ce, 7741baf2-abd6-4284-b23a-e8b0f0554e3a]

## Tensions and contradictions

- **Aging is targetable, but healthspan is undermeasured:** His geroscience optimism depends on the claim that aging can be slowed, while his own healthspan critique warns that the field often lacks the quantitative tools to prove its most attractive outcome. [46f2e5c9-8a5a-4f18-8238-4e9ac6e9ac36, c07d0ae5-1871-4232-bb71-d473af342d82]
- **Rapamycin is compelling, but translation is unresolved:** He presents rapamycin as unusually robust in animals, yet the same body of evidence exposes uncertainty about human dosing, side effects, formulation, immune effects, muscle effects, and tissue-specific mTOR inhibition. [7432e379-23da-4f3b-b84b-efe6214a76bf, 147151e2-c737-4a65-9785-918fca4ff95e]
- **Dogs make research more human-relevant and more messy:** Companion dogs provide real-world genetic and environmental diversity, but owner reports, heterogeneous veterinary data, home environments, and natural disease variation complicate clean causal inference. [070a08eb-b239-4f33-a4d3-979957108a19, 4f8e5556-8384-46ee-96f6-325cf12897ad]
- **Biomarkers are needed, but clocks can mislead:** He wants biomarkers to shorten trials and guide interventions, yet he criticizes direct-to-consumer biological-age tests as noisy, clinically unactionable, and easily confused with actual biological age. [cc6b772c-a46d-4edd-a850-5d5c1821698d, 7453a67b-e3fc-4142-8d8b-a150e25538ed]
- **Caloric restriction is powerful in animals, but not a simple human prescription:** He recognizes CR as one of the strongest lifespan interventions in laboratory animals while warning that hunger, poor thermal regulation, reproductive effects, immune concerns, muscle and bone tradeoffs, and social consequences matter in people. [7453a67b-e3fc-4142-8d8b-a150e25538ed, a74957a8-7a10-427e-a5b5-2c0d0168558e]
- **Public engagement is essential and risky:** The Dog Aging Project depends on citizen science, owner enthusiasm, and open communication, while his public role also involves warning that enthusiasm can become hype, mistrust, and commercialization without evidence. [0b6178ae-9a4f-40e8-882d-805fc079db68, 302f111f-88eb-4e5c-8ff7-0726f697b61c]
- **He critiques longevity commercialization while participating in translation:** His skepticism toward supplements, clocks, and clinics coexists with leadership in Optispan and other translational efforts, making his implied standard not anti-commercialism but evidence-governed commercialization. [d3efc056-06ae-4877-af68-4ef48dc6586d, 8b64aa70-d1bd-4ad9-b2f2-aec415dc86ba]
- **Model organisms are indispensable but insufficient:** Yeast, worms, flies, and mice reveal conserved mechanisms, yet he repeatedly emphasizes that laboratory conditions, species differences, genetic backgrounds, pathogen exposure, and endpoints limit direct human extrapolation. [08b666dd-92ba-45d9-a092-5f4c76936d3f, 9616de3f-893c-473d-8837-1a3d49ba0aca]

## Unifying threads

- **Conservation-to-translation is the master mechanism:** His career arc runs from yeast longevity genes and TOR signaling to mouse rapamycin, companion dog trials, biomarkers, and human clinical questions; the unifying move is always from conserved pathway to testable intervention. [08b666dd-92ba-45d9-a092-5f4c76936d3f, 27134374-687e-4c51-8d65-405012e47302]
- **Prevention is more powerful than rescue:** He repeatedly frames aging biology as the upstream terrain that shapes disease risk, implying that delaying the permissive state for disease may be more efficient than curing each disease after pathology is established. [157680c4-4dba-4e64-b398-944aade54b2a, 8b773a71-6629-4268-8ffb-e634d07f012d]
- **Function is the moral target:** Beneath lifespan curves and pathway diagrams, his practical target is preserved ability—throwing a ball, maintaining organ function, avoiding frailty, staying socially and physically capable—not merely producing younger-looking biomarkers. [7741baf2-abd6-4284-b23a-e8b0f0554e3a, 6a795436-bb7e-442b-8e23-7d9e451f6eb3]
- **Optimism is bounded by measurement:** He is optimistic because aging can be modified in animals and likely influenced in humans, but bounded because claims must be measured with validated endpoints, appropriate controls, and reproducible effects. [3e794561-7e4f-4127-b1d5-ee0bd502d194, 9991ff53-4225-47d9-b41c-1d408e4772e1]
- **The Dog Aging Project embodies his field-building style:** It combines longitudinal epidemiology, genetics, multi-omics, biomarkers, environmental data, owner participation, veterinary records, open data, and randomized rapamycin trials into a single geroscience platform. [070a08eb-b239-4f33-a4d3-979957108a19, 053d00cd-a5a1-4247-aff4-4ec19b49f7aa]
- **Rapamycin is a case study, not a religion:** He uses rapamycin to show how geroscience can progress from mechanism to mammals to clinical testing, but his repeated caveats make clear that no intervention escapes dose-response, safety, endpoint, and translation questions. [810e2339-9721-4f4a-b1cb-055ff645d1e6, 2c4d0258-5054-4f5c-98e8-d29a74d16549]
- **Credibility is a scientific resource:** His attacks on sloppy clocks, reversal claims, supplement hype, short-lived controls, and overconfident diet narratives all serve one larger concern: bad claims waste resources and make serious aging biology look like charlatanism. [7453a67b-e3fc-4142-8d8b-a150e25538ed, ff5aaf19-375e-43b8-bff1-5f124751c6a0]
- **Aging science is for pets and people together:** His work gives companion animals independent moral and scientific importance: dogs are not just models for humans, but beneficiaries of healthspan research whose results may also accelerate human geroscience. [b315ff2c-58ff-44fb-a8e7-68bd623e868a, 143adea2-995d-450e-97ec-b8130e7a01ad]

## Sources

- Targeting the biology of aging with mTOR inhibitors | Nature Aging · nature.com — https://www.nature.com/articles/s43587-023-00416-y
- What is the clinical evidence to support off-label rapamycin therapy ... · aging-us.com — https://www.aging-us.com/article/206300/text
- Dog Aging Project Test of Rapamycin in Aging Dogs (TRIAD) · vet.tufts.edu — https://vet.tufts.edu/clinical-trials/dog-aging-project-test-rapamycin-aging-dogs-triad
- Rapamycin enhances survival in a Drosophila model of mitochondrial disease · oncotarget.com — https://www.oncotarget.com/article/12560
- An open science study of ageing in companion dogs - PMC - NIH · pmc.ncbi.nlm.nih.gov — https://pmc.ncbi.nlm.nih.gov/articles/PMC8940555
- An open science study of ageing in companion dogs - PubMed · pubmed.ncbi.nlm.nih.gov — https://pubmed.ncbi.nlm.nih.gov/35110758
- A randomized controlled trial to establish effects of short-term ... - PMC · pmc.ncbi.nlm.nih.gov — https://pmc.ncbi.nlm.nih.gov/articles/PMC5411365
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- Resveratrol and rapamycin: are they anti-aging... : Bioessays · ovid.com — https://www.ovid.com/journals/bioe/pdf/10.1002/bies.200900171~resveratrol-and-rapamycin-are-they-anti-aging-drugs
- Accuracy of owner-reported diagnoses for dogs enrolled in the Dog Aging Project as compared to veterinary electronic medical records | PLOS One · journals.plos.org — https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0342427
- Our Mission - Dog Aging Project · dogagingproject.org — https://dogagingproject.org/project-details
- Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience | GeroScience | Springer Nature Link · link.springer.com — https://link.springer.com/article/10.1007/s11357-025-01571-3
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- mTOR at the nexus of nutrition, growth, ageing and disease | Nature Reviews Molecular Cell Biology · nature.com — https://www.nature.com/articles/s41580-019-0199-y
- functional aspects still trump molecular parameters | npj Aging - Nature · nature.com — https://www.nature.com/articles/s41514-025-00207-2
- Recommendations for biomarker data collection in clinical trials by ... · nature.com — https://www.nature.com/articles/s41514-025-00313-1
- Yeast replicative aging: a paradigm for defining conserved longevity ... · academic.oup.com — https://academic.oup.com/femsyr/article/14/1/148/510501
- Dog aging project TRIAD study - WSU Veterinary Teaching Hospital · hospital.vetmed.wsu.edu — https://hospital.vetmed.wsu.edu/2022/03/27/dog-aging-project-triad-study
- Dogs and humans share biomarkers of mortality - Dog Aging Project · dogagingproject.org — https://dogagingproject.org/dogs-and-humans-share-biomarkers-of-mortality
- Scientific Results: A review of frailty instruments in human medicine ... · dogagingproject.org — https://dogagingproject.org/scientific-results-a-review-of-frailty-instruments-in-human-medicine-and-proposal-of-a-frailty-instrument-for-dogs
- What is Citizen Science? | Dog Aging Project · dogagingproject.org — https://dogagingproject.org/citizen-science
- Report Increased Mammalian Lifespan and a Segmental and Tissue ... · sciencedirect.com — https://www.sciencedirect.com/science/article/pii/S2211124713003926
- Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients · science.org — https://www.science.org/doi/10.1126/science.1115535
- Biomarkers of aging: from molecules and surrogates to physiology ... · journals.physiology.org — https://journals.physiology.org/doi/abs/10.1152/physrev.00045.2024
- Dr. Matt Ranks Longevity Supplements: The Winners and Total Scams — Optispan · optispan.life — https://www.optispan.life/podcast/v/8bgp7w5ccthjxd867c7lbx79fak7mp
- The Peter Attia Drive - #175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process Transcript and Discussion · podscripts.co — https://podscripts.co/podcasts/the-peter-attia-drive/175-matt-kaeberlein-phd-the-biology-of-aging-rapamycin-and-other-interventions-that-target-the-aging-process
- #175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process - Peter Attia · peterattiamd.com — https://peterattiamd.com/mattkaeberlein2
- #32 “Medical malpractice”: Matt Kaeberlein on biological age tests - LEVITY | Acast · shows.acast.com — https://shows.acast.com/levity-the-longevity-podcast/episodes/ep-32-matt-kaeber
- Ask a Longevity Scientist: Testosterone, "Miracle" Supplements & Falling for the Hype — Optispan · optispan.life — https://www.optispan.life/podcast/v/r983s4x4cl4475k76ymbachltwz2yb
- Matt Kaeberlein discusses healthspan, longevity, and rapamycin · ihmc.us — https://www.ihmc.us/stemtalk/episode-139
- Episode 58: The 4 Pillars of Longevity & Healthspan: Eat, Move, Sleep, Connect with Dr. Matt Kaeberlein | The Dr Kumar Discovery · drkumardiscovery.com — https://drkumardiscovery.com/podcast/the-4-pillars-of-longevity-and-healthspan-eat-move-sleep-connect-dr-matt-kaeberlein
- Longevity biomarkers for healthy aging — Dr. Matt Kaeberlein | A Whole New Level | Levels | Levels · levels.com — https://www.levels.com/podcasts/longevity-biomarkers-healthy-aging-kaeberlein
- 19. Biological Aging Clocks, mTOR & Rapamycin: A Reality Check with Dr. Matt Kaeberlein - MD Longevity Lab: Playing the Long Game with Drs. Vikas and Nisha Patel | iHeart · iheart.com — https://www.iheart.com/podcast/1323-md-longevity-lab-playing-275863341/episode/19-biological-aging-clocks-mtor-314688993
- Rapamycin, Longevity, and the Dog Aging Project with Dr. Matt Kaeberlein - The Healthspan Collective · thehealthspancollective.com — https://thehealthspancollective.com/rapamycin-longevity-and-the-dog-aging-project-with-dr-matt-kaeberlein
- Matt Kaeberlein - Healthy Aging and Longevity Research Institute · halo.dlmp.uw.edu — https://halo.dlmp.uw.edu/people/matt-kaeberlein
- How healthy is the healthspan concept? - PMC - NIH · pmc.ncbi.nlm.nih.gov — https://pmc.ncbi.nlm.nih.gov/articles/PMC6136295
- Healthspan, Longevity and Interventions that Target the Aging ... · steeringpoint.ie — https://steeringpoint.ie/podcast/healthspan-longevity-and-interventions-that-target-the-aging-process
- The Truth About Today’s Hottest Anti-Aging Drugs with Dr. Matt Kaeberlein - E78 by @Andrew McConnell · Zencastr Video · zencastr.com — https://zencastr.com/z/WGEMZxMI
- How Did the Dog Aging Project Begin? · dogagingproject.org — https://dogagingproject.org/how-did-the-dog-aging-project-begin
- Targeting Mechanisms of Aging Cross Species - ideaXme · radioideaxme.com — https://radioideaxme.com/2020/07/08/targeting-mechanisms-of-aging-cross-species
- Aging Interventions - Rapamycin, NAD+ & Dog Aging Project | Matt Kaeberlein · livelongerworld.com — https://www.livelongerworld.com/p/mkaeberlein
- Longevity Rapid Fire with Dr. Matt Kaeberlein: Hype, Hope, and What Actually Works | Ep. 395 - PodcastHealth · podcasthealth.com — https://podcasthealth.com/podcast/longevity-rapid-fire-with-dr-matt-kaeberlein-hype-hope-and-what-actually-works-ep-395
- The Science of Aging and How to Slow It Down | Dr. Matt Kaeberlein | The Proof Podcast EP 249 transcript · youtube.com — https://www.youtube.com/watch?v=ROZx14XPVI0
- Longevity: Separating the Science From the Fiction | Matt Kaeberlein | TEDxBoston transcript · youtube.com — https://www.youtube.com/watch?v=JQ53zRcSaLk
- Biology of aging and tips to slow it down | Matt Kaeberlein, PhD · theproof.com — https://theproof.com/biology-of-aging-and-tips-to-slow-it-down-matt-kaeberlein-phd
- Understanding Biological Aging: Insights from Dr. Matt Kaeberlein · modernthyroidclinic.com — https://www.modernthyroidclinic.com/podcast/the-truth-about-biological-age---what-really-slows-aging-with-dr-matt-kaeberlein
- Dr. Matt Kaeberlein on The Dog Aging Project ... - Tim Ferriss · tim.blog — https://tim.blog/2022/07/30/matt-kaeberlein-life-extension-transcript
- The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More (#610) - The Blog of Author Tim Ferriss · tim.blog — https://tim.blog/2022/07/27/matt-kaeberlein-life-extension
- Episode 48: Decoding Aging: Science, Healthspan, and the Future of Longevity with Dr. Matt Kaeberlein - Your Lifestyle Is Your Medicine | Lyssna här | Poddtoppen.se · poddtoppen.se — https://poddtoppen.se/podcast/1629096669/your-lifestyle-is-your-medicine/episode-48-decoding-aging-science-healthspan-and-the-future-of-longevity-with-dr-matt-kaeberlein
- An introduction to the study of RAPAMYCIN | 6 - R-Files w/ Matt Kaeberlein — Optispan · optispan.life — https://www.optispan.life/podcast/v/an-introduction-to-the-study-of-rapamycin-6-rfiles-w-matt-kaeberlein-f5j46
- Answering Your Questions on Rapamycin: Optimal doses, tests, & stacks | 20 - AMA #3 — Optispan · optispan.life — https://www.optispan.life/podcast/v/answering-your-questions-on-rapamycin-optimal-doses-tests-stacks-20-ama-3-p5c6f
- Longevity Rapid Fire With Dr. Matt Kaeberlein: Hype, Hope, And What Actually Works | Ep. 395 » BabyBoomer.org · babyboomer.org — https://babyboomer.org/shows/aging-well-podcast/longevity-rapid-fire-with-dr-matt-kaeberlein-hype-hope-and-what-actually-works-ep-395
- The Science of Transforming Inputs for Enhanced Value and Efficiency · looong.ai — https://looong.ai/video/the-science-of-transforming-inputs-for-enhanced-value-and-efficiency
- Episode 67: Longevity: What we know and what we need to know about living longer and better – The Original Guide To Mens Health · theoriginalguidetomenshealth.org — https://theoriginalguidetomenshealth.org/podcast/episode-67-longevity-what-we-know-and-what-we-need-to-know-about-living-longer-and-better
- The Future Of Longevity | Prof Matt Kaeberlein Ep6/6 | Listen Notes · listennotes.com — https://www.listennotes.com/es/podcasts/modern-healthspan/the-future-of-longevity-prof-26ZqkO3t-Fb
- Amol Sarva's weblog - Matt Kaeberlein on which longevity supplements might really work, and which don’t Amol Sarva's weblog · amol.sarva.co — https://amol.sarva.co/podcast/matt-kaeberlein-on-which-longevity-supplements-might-really-work-and-which-dont
- Super U Podcast | Eat, Move, Sleep, Connect: The Four Pillars of Longevity with Dr. Matt Kaeberlein | Erik Qualman · equalman.com — https://equalman.com/the-four-pillars-of-longevity-with-dr-matt-kaeberlein
- Subjects · nature.com — https://www.nature.com/articles/s41586-021-04282-9
- PERMALINK · ncbi.nlm.nih.gov — https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411365
- How healthy is the healthspan concept? | GeroScience | Springer Nature Link · link.springer.com — https://link.springer.com/article/10.1007/s11357-018-0036-9
- Abstract · pubmed.ncbi.nlm.nih.gov — https://pubmed.ncbi.nlm.nih.gov/27384492
- TEDxBoston | TED · ted.com — https://www.ted.com/tedx/events/67397
- How To Increase Longevity: The Science Of Aging With Dr. Matt Kaeberlein – Liv HEALTH · livhealth.com — https://livhealth.com/increase-longevity-aging
- #5 - Matt Kaeberlein | Aging Interventions - Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project transcript · youtu.be — https://youtu.be/BL67DhNepfg
- LONGEVITY Biomarkers for HEALTHY AGING and Well-Being | Dr. Matt Kaeberlein & Mike Haney transcript · youtube.com — https://www.youtube.com/watch?v=OPH5Nb2a69o
- #10 – Matt Kaeberlein, Ph.D.: rapamycin and dogs — living longer, healthier & turning back the clock transcript · youtube.com — https://www.youtube.com/watch?v=kE-ep1kBziQ
- Can Aging Be Hacked? | Matt Kaeberlein | Escaped Sapiens #90 transcript · youtube.com — https://www.youtube.com/watch?v=Q5ZOc_UzF1U
- Matt Kaeberlein on Rapamycin Longevity Series | Lessons learned from 2 decades of Rapamycin research transcript · youtube.com — https://www.youtube.com/watch?v=PFKuxj5T6GA
- Rapamycin: A drug that may slow aging with Matt Kaeberlein, PhD transcript · youtube.com — https://www.youtube.com/watch?v=7VZEzXQVeBE
- RAPAMYCIN, mTOR & LONGEVITY: WHAT SCIENCE REALLY SHOWS | 091 MATT KAEBERLEIN, PhD transcript · youtube.com — https://www.youtube.com/watch?v=HFVdBN1M02s
- Caloric restriction's impact on muscle mass, strength, and the immune system | Matt Kaeberlein transcript · youtube.com — https://www.youtube.com/watch?v=2If31DruBsg
- What are epigenetic clocks used for? | Matt Kaeberlein and Peter Attia transcript · youtube.com — https://www.youtube.com/watch?v=-xcvWKurtPI
- Can a Drug Slow Aging? The Rapamycin Story · pharmacy.arizona.edu — https://www.pharmacy.arizona.edu/news/2026/can-drug-slow-aging-rapamycin-story
- #272 ‒ Rapamycin: potential longevity benefits, surge in ... · peterattiamd.com — https://peterattiamd.com/davidsabatini-mattkaeberlein
- Recording and Transcript Available: “How Realistic is a 100-year ... · afar.org — https://www.afar.org/news/recording-and-transcript-available-how-realistic-is-a-100-year-life-expectancy-and-why-does-it-matter-webinar
- Matt Kaeberlein: 11 aging supplements, reviewed · agingwithstrength.com — https://www.agingwithstrength.com/p/matt-kaeberlein-the-problem-with-longevity-medicine-and-supplements
- Matt Kaeberlein - The Dog Aging Project | Our Longevity Futures · gowinglife.com — https://www.gowinglife.com/matt-kaeberlein-the-dog-aging-project-our-longevity-futures-ep-16
- Targeting Biological Aging: A New Paradigm for 21st Century ... · slideshare.net — https://www.slideshare.net/slideshow/targeting-biological-aging-a-new-paradigm-for-21st-century-medicine/246647487
- 222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D. transcript · youtube.com — https://www.youtube.com/watch?v=4sqyGwqyAao
- 272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more transcript · youtube.com — https://www.youtube.com/watch?v=O67pvKxio10
- Healthy aging: The ultimate preventative medicine - PubMed - NIH · pubmed.ncbi.nlm.nih.gov — https://pubmed.ncbi.nlm.nih.gov/26785476
- mTOR Inhibition: From Aging to Autism and Beyond - PubMed - NIH · pubmed.ncbi.nlm.nih.gov — https://pubmed.ncbi.nlm.nih.gov/24379984
- Rapamycin and aging: When, for how long, and how much? - PMC · pmc.ncbi.nlm.nih.gov — https://pmc.ncbi.nlm.nih.gov/articles/PMC4401992
- An epigenetic biomarker of aging for lifespan and healthspan · pubmed.ncbi.nlm.nih.gov — https://pubmed.ncbi.nlm.nih.gov/29676998
- A masked, placebo-controlled, randomized clinical trial evaluating ... · frontiersin.org — https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2023.1168711/full
- Test of Rapamycin in Aging Dogs (TRIAD): study design and ... · pmc.ncbi.nlm.nih.gov — https://pmc.ncbi.nlm.nih.gov/articles/PMC12181551
- Targeting the biology of aging with mTOR inhibitors - PMC - NIH · pmc.ncbi.nlm.nih.gov — https://pmc.ncbi.nlm.nih.gov/articles/PMC10330278
- Scientific Results: Development and evaluation of a survey ... · dogagingproject.org — https://dogagingproject.org/scientific-results-development-and-evaluation-of-a-survey-instrument-to-assess-veterinary-medical-record-suitability-for-multi-center-research-studies
- The Dog Aging Project: Test of Rapamycin in Aging Dogs · veterinaryclinicaltrials.org — https://veterinaryclinicaltrials.org/s/the-dog-aging-project-test-of-rapamycin-in-aging-dogs-432887
- Study to assess healthy aging in dogs: the Dog Aging Project and ... · vet.uga.edu — https://vet.uga.edu/clinical-trial/study-to-assess-healthy-aging-in-dogs-the-dog-aging-project-and-test-of-rapamycin-in-aging-dogs-triad-study
- Rapamycin in aging and disease: maximizing efficacy while ... · oncotarget.com — https://www.oncotarget.com/article/10381/text
- Triad Fast Track - Dog Aging Project · dogagingproject.org — https://dogagingproject.org/triad
- Inside TRIAD: Introducing the Test of Rapamycin in Aging ... · dogagingproject.org — https://dogagingproject.org/inside-science-introducing-the-test-of-rapamycin-in-aging-dogs
- Dog Aging Project - Veterinary Clinical Trials Registry · veterinaryclinicaltrials.org — https://veterinaryclinicaltrials.org/s/dog-aging-project-757445
- Antiaging diets: Separating fact from fiction - Science · science.org — https://www.science.org/doi/10.1126/science.abe7365
- The impact of short-lived controls on the interpretation of lifespan ... · sciencedirect.com — https://www.sciencedirect.com/science/article/abs/pii/S1568163724003301
- Protein Catabolites as Blood‐Based Biomarkers of Aging ... · onlinelibrary.wiley.com — https://onlinelibrary.wiley.com/doi/full/10.1111/acel.70226
- ExplaiNAble BioLogical Age (ENABL Age): an artificial ... · thelancet.com — https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00189-7/fulltext
- The Dog Aging Project End of Life Survey reveals owners ... · avmajournals.avma.org — https://avmajournals.avma.org/view/journals/javma/aop/javma.25.12.0863/javma.25.12.0863.xml

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